Distinct roles of XRCC4 and Ku80 in non-homologous end-joining of endonuclease- and ionizing radiation-induced DNA double-strand breaks

Non-homologous end-joining (NHEJ) of DNA double-strand breaks (DSBs) is mediated by two protein complexes comprising Ku80/Ku70/DNA-PKcs/Artemis and XRCC4/LigaseIV/XLF. Loss of Ku or XRCC4/LigaseIV function compromises the rejoining of radiation-induced DSBs and leads to defective V(D)J recombination...

Full description

Saved in:
Bibliographic Details
Main Authors: Schulte-Uentrop, Leonie, El-Awady, Raafat A., Schliecker, Lena, Willers, Henning, Dahm-Daphi, Jochen
Format: Artigo
Language:Inglês
Published: Oxford University Press 2008
Subjects:
Molecular Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2377445/
https://ncbi.nlm.nih.gov/pubmed/18332040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn094
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items