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Defects in XRCC4 and KU80 differentially affect the joining of distal nonhomologous ends

XRCC4-null mice have a more severe phenotype than KU80-null mice. Here, we address whether this difference in phenotype is connected to nonhomologous end-joining (NHEJ). We used intrachromosomal substrates to monitor NHEJ of two distal double-strand breaks (DSBs) targeted by I-SceI, in living cells....

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Autores principales: Guirouilh-Barbat, Josée, Rass, Emilie, Plo, Isabelle, Bertrand, Pascale, Lopez, Bernard S.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2007
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2409239/
https://ncbi.nlm.nih.gov/pubmed/18093953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0708541104
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