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Defects in XRCC4 and KU80 differentially affect the joining of distal nonhomologous ends
XRCC4-null mice have a more severe phenotype than KU80-null mice. Here, we address whether this difference in phenotype is connected to nonhomologous end-joining (NHEJ). We used intrachromosomal substrates to monitor NHEJ of two distal double-strand breaks (DSBs) targeted by I-SceI, in living cells....
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2007
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2409239/ https://ncbi.nlm.nih.gov/pubmed/18093953 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0708541104 |
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