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The Cohesion complex maintains genome stability by preventing end joining of distant DNA ends in S phase
Genome instability is a hallmark of cancer cells. The joining of distant DNA double-strand ends (DSEs) ineluctably leads to genome rearrangements. We found that the cohesion complex maintains genome stability by repressing the joining of distant DSEs specifically in the S phase, i.e., the main phase...
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| Опубликовано в: : | Mol Cell Oncol |
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| Главные авторы: | , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Taylor & Francis
2018
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6149804/ https://ncbi.nlm.nih.gov/pubmed/30250878 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2016.1154123 |
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