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The cohesin complex prevents the end-joining of distant DNA double-strand ends in S phase: Consequences on genome stability maintenance

DNA double-strand break (DSB) repair is essential for genome stability maintenance, but the joining of distant DNA double strand ends (DSEs) inevitably leads to genome rearrangements. Therefore, DSB repair should be tightly controlled to secure genome stability while allowing genetic variability. Te...

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Publicado en:Nucleus
Main Authors: Gelot, Camille, Guirouilh-Barbat, Josée, Lopez, Bernard S.
Formato: Artigo
Idioma:Inglês
Publicado: Taylor & Francis 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5039006/
https://ncbi.nlm.nih.gov/pubmed/27326661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19491034.2016.1194159
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