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The cohesin complex prevents the end-joining of distant DNA double-strand ends in S phase: Consequences on genome stability maintenance

DNA double-strand break (DSB) repair is essential for genome stability maintenance, but the joining of distant DNA double strand ends (DSEs) inevitably leads to genome rearrangements. Therefore, DSB repair should be tightly controlled to secure genome stability while allowing genetic variability. Te...

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Detalhes bibliográficos
Publicado no:Nucleus
Main Authors: Gelot, Camille, Guirouilh-Barbat, Josée, Lopez, Bernard S.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5039006/
https://ncbi.nlm.nih.gov/pubmed/27326661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19491034.2016.1194159
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