53BP1 Protects against CtIP-Dependent Capture of Ectopic Chromosomal Sequences at the Junction of Distant Double-Strand Breaks

DNA double-strand breaks (DSB) are very harmful lesions that can generate genome rearrangements. In this study, we used intrachromosomal reporters to compare both the efficiency and accuracy of end-joining occurring with close (34 bp apart) vs. distant DSBs (3200 bp apart) in human fibroblasts. We s...

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Bibliografiske detaljer
Udgivet i:PLoS Genet
Main Authors: Guirouilh-Barbat, Josée, Gelot, Camille, Xie, Anyong, Dardillac, Elodie, Scully, Ralph, Lopez, Bernard S.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5087911/
https://ncbi.nlm.nih.gov/pubmed/27798638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006230
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