Role of the double-strand break repair pathway in the maintenance of genomic stability

DNA double-strand breaks (DSBs) are highly lethal lesions that jeopardize genome integrity. However, DSBs are also used to generate diversity during the physiological processes of meiosis or establishment of the immune repertoire. Therefore, DSB repair must be tightly controlled. Two main strategies...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Mol Cell Oncol
Hauptverfasser: Le Guen, Tangui, Ragu, Sandrine, Guirouilh-Barbat, Josée, Lopez, Bernard S
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2014
Schlagworte:
Review
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4905226/
https://ncbi.nlm.nih.gov/pubmed/27308383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/23723548.2014.968020
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