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Role of the double-strand break repair pathway in the maintenance of genomic stability

DNA double-strand breaks (DSBs) are highly lethal lesions that jeopardize genome integrity. However, DSBs are also used to generate diversity during the physiological processes of meiosis or establishment of the immune repertoire. Therefore, DSB repair must be tightly controlled. Two main strategies...

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Detalhes bibliográficos
Publicado no:Mol Cell Oncol
Main Authors: Le Guen, Tangui, Ragu, Sandrine, Guirouilh-Barbat, Josée, Lopez, Bernard S
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4905226/
https://ncbi.nlm.nih.gov/pubmed/27308383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/23723548.2014.968020
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