Ubiquitylation of Ku80 by RNF126 Promotes Completion of Nonhomologous End Joining-Mediated DNA Repair

Repair of damaged DNA is critical for maintenance of genetic information. In eukaryotes, DNA double-strand breaks (DSBs) are recognized by the Ku70-Ku80 heterodimer, which then recruits proteins that mediate repair by nonhomologous end joining (NHEJ). Prolonged retention of Ku70/80 at DSBs prevents...

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Publicat a:Mol Cell Biol
Autors principals: Ishida, Noriko, Nakagawa, Tadashi, Iemura, Shun-Ichiro, Yasui, Akira, Shima, Hiroki, Katoh, Yasutake, Nagasawa, Yuko, Natsume, Toru, Igarashi, Kazuhiko, Nakayama, Keiko
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2017
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5288581/
https://ncbi.nlm.nih.gov/pubmed/27895153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00347-16
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