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PARP regulates nonhomologous end joining through retention of Ku at double-strand breaks
Poly adenosine diphosphate (ADP)–ribosylation (PARylation) by poly ADP-ribose (PAR) polymerases (PARPs) is an early response to DNA double-strand breaks (DSBs). In this paper, we exploit Dictyostelium discoideum to uncover a novel role for PARylation in regulating nonhomologous end joining (NHEJ). P...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
The Rockefeller University Press
2011
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3153639/ https://ncbi.nlm.nih.gov/pubmed/21807880 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201012132 |
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