PARP regulates nonhomologous end joining through retention of Ku at double-strand breaks

Poly adenosine diphosphate (ADP)–ribosylation (PARylation) by poly ADP-ribose (PAR) polymerases (PARPs) is an early response to DNA double-strand breaks (DSBs). In this paper, we exploit Dictyostelium discoideum to uncover a novel role for PARylation in regulating nonhomologous end joining (NHEJ). P...

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Main Authors: Couto, C. Anne-Marie, Wang, Hong-Yu, Green, Joanna C.A., Kiely, Rhian, Siddaway, Robert, Borer, Christine, Pears, Catherine J., Lakin, Nicholas D.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2011
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3153639/
https://ncbi.nlm.nih.gov/pubmed/21807880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201012132
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