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The alternative end-joining pathway for repair of DNA double-strand breaks requires PARP1 but is not dependent upon microhomologies

Non-homologous end-joining (NHEJ), the major repair pathway for DNA double-strand breaks (DSB) in mammalian cells, employs a repertoire of core proteins, the recruitment of which to DSB-ends is Ku-dependent. Lack of either of the core components invariably leads to a repair deficiency. There has bee...

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Autori principali: Mansour, Wael Y., Rhein, Tim, Dahm-Daphi, Jochen
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2952854/
https://ncbi.nlm.nih.gov/pubmed/20483915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq387
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