Inhibition of PARP1‐dependent end‐joining contributes to Olaparib‐mediated radiosensitization in tumor cells

Poly‐ADP‐ribose‐polymerase inhibitors (PARPi) are considered to be optimal tools for specifically enhancing radiosensitivity. This effect has been shown to be replication‐dependent and more profound in HR‐deficient tumors. Here, we present a new mode of PARPi‐mediated radiosensitization which was ob...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Mol Oncol
मुख्य लेखकों: Kötter, Annika, Cornils, Kerstin, Borgmann, Kerstin, Dahm-Daphi, Jochen, Petersen, Cordula, Dikomey, Ekkehard, Mansour, Wael Y.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: John Wiley and Sons Inc. 2014
विषय:
Research Articles
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC5528607/
https://ncbi.nlm.nih.gov/pubmed/25028150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2014.06.008
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