EGF Receptor Inhibition Radiosensitizes NSCLC Cells By Inducing Senescence In Cells Sustaining DNA Double-Strand Breaks

The mechanisms by which inhibition of the epidermal growth factor receptor (EGFR) sensitizes non-small cell lung cancer (NSCLC) cells to ionizing radiation remain poorly understood. We set out to characterize the radiosensitizing effects of the tyrosine kinase inhibitor erlotinib and the monoclonal...

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Hlavní autoři: Wang, Meng, Morsbach, Fabian, Sander, David, Gheorghiu, Liliana, Nanda, Akash, Benes, Cyril, Kriegs, Malte, Krause, Mechthild, Dikomey, Ekkehard, Baumann, Michael, Dahm-Daphi, Jochen, Settleman, Jeffrey, Willers, Henning
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3185115/
https://ncbi.nlm.nih.gov/pubmed/21852385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-11-0213
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