Radiation resistance in KRAS-mutated lung cancer is enabled by stem-like properties mediated by an osteopontin-EGFR pathway

Lung cancers with activating KRAS mutations are characterized by treatment resistance and poor prognosis. In particular, the basis for their resistance to radiation therapy is poorly understood. Here we describe a radiation resistance phenotype conferred by a stem-like subpopulation characterized by...

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Publicado no:Cancer Res
Main Authors: Wang, Meng, Han, Jing, Marcar, Lynnette, Black, Josh, Liu, Qi, Li, Xiangyong, Nagulapalli, Kshithija, Sequist, Lecia V., Mak, Raymond H., Benes, Cyril H., Hong, Theodore S., Gurtner, Kristin, Krause, Mechthild, Baumann, Michael, Kang, Jing X., Whetstine, Johnathan R., Willers, Henning
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5445902/
https://ncbi.nlm.nih.gov/pubmed/28202526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-0808
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