Significance of targeted therapy and genetic alterations in EGFR, ALK, or KRAS on survival in patients with non–small cell lung cancer treated with radiotherapy for brain metastases

BACKGROUND: We determined the impact of genetic alterations in EGFR, ALK, or KRAS on survival after radiotherapy for brain metastases in non–small cell lung cancer (NSCLC). METHODS: Of 172 genotyped NSCLC patients treated with radiotherapy for brain metastases in 2005–2012, 54 had cancers with EGFR...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Mak, Kimberley S., Gainor, Justin F., Niemierko, Andrzej, Oh, Kevin S., Willers, Henning, Choi, Noah C., Loeffler, Jay S., Sequist, Lecia V., Shaw, Alice T., Shih, Helen A.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
Assuntos:
Clinical Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4288518/
https://ncbi.nlm.nih.gov/pubmed/25053852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou146
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