Radiation resistance in KRAS-mutated lung cancer is enabled by stem-like properties mediated by an osteopontin-EGFR pathway

Lung cancers with activating KRAS mutations are characterized by treatment resistance and poor prognosis. In particular, the basis for their resistance to radiation therapy is poorly understood. Here we describe a radiation resistance phenotype conferred by a stem-like subpopulation characterized by...

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Опубликовано в: :Cancer Res
Главные авторы: Wang, Meng, Han, Jing, Marcar, Lynnette, Black, Josh, Liu, Qi, Li, Xiangyong, Nagulapalli, Kshithija, Sequist, Lecia V., Mak, Raymond H., Benes, Cyril H., Hong, Theodore S., Gurtner, Kristin, Krause, Mechthild, Baumann, Michael, Kang, Jing X., Whetstine, Johnathan R., Willers, Henning
Формат: Artigo
Язык:Inglês
Опубликовано: 2017
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5445902/
https://ncbi.nlm.nih.gov/pubmed/28202526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-0808
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