Identification of CDCP1 as a hypoxia-inducible factor 2α (HIF-2α) target gene that is associated with survival in clear cell renal cell carcinoma patients

CUB domain-containing protein 1 (CDCP1) is a transmembrane protein that is highly expressed in stem cells and frequently overexpressed and tyrosine-phosphorylated in cancer. CDCP1 promotes cancer cell metastasis. However, the mechanisms that regulate CDCP1 are not well-defined. Here we show that hyp...

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Detalhes bibliográficos
Main Authors: Emerling, Brooke M., Benes, Cyril H., Poulogiannis, George, Bell, Eric L., Courtney, Kevin, Liu, Hui, Choo-Wing, Rayman, Bellinger, Gary, Tsukazawa, Kazumi S., Brown, Victoria, Signoretti, Sabina, Soltoff, Stephen P., Cantley, Lewis C.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3587206/
https://ncbi.nlm.nih.gov/pubmed/23378636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1222435110
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