Depletion of a Putatively Druggable Class of Phosphatidylinositol Kinases Inhibits Growth of p53-Null Tumors

Here, we show that a subset of breast cancers express high levels of the type 2 phosphatidylinositol-5-phosphate 4-kinases α and/or β (PI5P4Kα and β) and provide evidence that these kinases are essential for growth in the absence of p53. Knocking down PI5P4Kα and β in a breast cancer cell line beari...

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Detalhes bibliográficos
Main Authors: Emerling, Brooke M., Hurov, Jonathan B., Poulogiannis, George, Tsukazawa, Kazumi S., Choo-Wing, Rayman, Wulf, Gerburg M., Bell, Eric L., Shim, Hye-Seok, Lamia, Katja A., Rameh, Lucia E., Bellinger, Gary, Sasaki, Atsuo T., Asara, John M., Yuan, Xin, Bullock, Andrea, DeNicola, Gina M., Song, Jiaxi, Brown, Victoria, Signoretti, Sabina, Cantley, Lewis C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4070383/
https://ncbi.nlm.nih.gov/pubmed/24209622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.09.057
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