Deletion of the gene Pip4k2c, a novel phosphatidylinositol kinase, results in hyperactivation of the immune system

Type 2 phosphatidylinositol-5-phosphate 4-kinase (PI5P4K) converts phosphatidylinositol-5-phosphate to phosphatidylinositol-4,5-bisphosphate. Mammals have three enzymes PI5P4Kα, PI5P4Kβ, and PI5P4Kγ, and these enzymes have been implicated in metabolic control, growth control, and a variety of stress...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Shim, Hyeseok, Wu, Chuan, Ramsamooj, Shivan, Bosch, Kaitlyn N., Chen, Zuojia, Emerling, Brooke M., Yun, Jihye, Liu, Hui, Choo-Wing, Rayman, Yang, Zhiwei, Wulf, Gerburg M., Kuchroo, Vijay Kumar, Cantley, Lewis C.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4941458/
https://ncbi.nlm.nih.gov/pubmed/27313209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1600934113
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