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Cell-to-cell variability in PI3K protein level regulates PI3K-AKT pathway activity in cell populations

BACKGROUND: Cell-to-cell variability in populations has been widely observed in mammalian cells. This heterogeneity can result from random stochastic events or can be deliberately maintained through regulatory processes. In the latter case, heterogeneity should confer a selective advantage that bene...

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Detalhes bibliográficos
Main Authors: Yuan, Tina L., Wulf, Gerburg, Burga, Laura, Cantley, Lewis C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3394538/
https://ncbi.nlm.nih.gov/pubmed/21256021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2010.12.047
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