Functional characterization of an isoform-selective inhibitor of PI3K-p110β as a potential anti-cancer agent

Genetic approaches have demonstrated that the p110β isoform of PI3K is essential for the growth of PTEN-null tumors. Thus, it is desirable to develop p110β-specific inhibitors for cancer therapy. Using a panel of PI3K isoform-specific cellular assays, we screened a collection of compounds possessing...

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Main Authors: Ni, Jing, Liu, Qingsong, Xie, Shaozhen, Carlson, Coby B., Von, Thanh, Vogel, Kurt W., Riddle, Steve M., Benes, Cyril H., Eck, Michael J., Roberts, Thomas M, Gray, Nathanael S., Zhao, Jean J.
格式: Artigo
語言:Inglês
出版: 2012
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3384541/
https://ncbi.nlm.nih.gov/pubmed/22588880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-12-0003
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