Hematopoiesis and RAS-driven myeloid leukemia differentially require PI3K isoform p110α

The genes encoding RAS family members are frequently mutated in juvenile myelomonocytic leukemia (JMML) and acute myeloid leukemia (AML). RAS proteins are difficult to target pharmacologically; therefore, targeting the downstream PI3K and RAF/MEK/ERK pathways represents a promising approach to treat...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
Main Authors: Gritsman, Kira, Yuzugullu, Haluk, Von, Thanh, Yan, Howard, Clayton, Linda, Fritsch, Christine, Maira, Sauveur-Michel, Hollingworth, Gregory, Choi, Christine, Khandan, Tulasi, Paktinat, Mahnaz, Okabe, Rachel O., Roberts, Thomas M., Zhao, Jean J.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2014
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3973083/
https://ncbi.nlm.nih.gov/pubmed/24569456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI69927
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki