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Hematopoiesis and RAS-driven myeloid leukemia differentially require PI3K isoform p110α

The genes encoding RAS family members are frequently mutated in juvenile myelomonocytic leukemia (JMML) and acute myeloid leukemia (AML). RAS proteins are difficult to target pharmacologically; therefore, targeting the downstream PI3K and RAF/MEK/ERK pathways represents a promising approach to treat...

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Détails bibliographiques
Auteurs principaux: Gritsman, Kira, Yuzugullu, Haluk, Von, Thanh, Yan, Howard, Clayton, Linda, Fritsch, Christine, Maira, Sauveur-Michel, Hollingworth, Gregory, Choi, Christine, Khandan, Tulasi, Paktinat, Mahnaz, Okabe, Rachel O., Roberts, Thomas M., Zhao, Jean J.
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2014
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3973083/
https://ncbi.nlm.nih.gov/pubmed/24569456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI69927
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