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PI3K in cancer: divergent roles of isoforms, modes of activation, and therapeutic targeting
Phosphatidylinositol 3-Kinases (PI3Ks) are critical coordinators of intracellular signaling in response to extracellular stimuli. Hyperactivation of PI3K signaling cascades is one of the most common events in human cancers. In this Review, we discuss recent advances in our knowledge of the roles of...
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| Publicado no: | Nat Rev Cancer |
|---|---|
| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4384662/ https://ncbi.nlm.nih.gov/pubmed/25533673 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrc3860 |
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