Hematopoiesis and RAS-driven myeloid leukemia differentially require PI3K isoform p110α

The genes encoding RAS family members are frequently mutated in juvenile myelomonocytic leukemia (JMML) and acute myeloid leukemia (AML). RAS proteins are difficult to target pharmacologically; therefore, targeting the downstream PI3K and RAF/MEK/ERK pathways represents a promising approach to treat...

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Detaylı Bibliyografya
Asıl Yazarlar: Gritsman, Kira, Yuzugullu, Haluk, Von, Thanh, Yan, Howard, Clayton, Linda, Fritsch, Christine, Maira, Sauveur-Michel, Hollingworth, Gregory, Choi, Christine, Khandan, Tulasi, Paktinat, Mahnaz, Okabe, Rachel O., Roberts, Thomas M., Zhao, Jean J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Clinical Investigation 2014
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3973083/
https://ncbi.nlm.nih.gov/pubmed/24569456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI69927
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