Constitutively active AKT depletes hematopoietic stem cells and induces leukemia in mice

Human cancers, including acute myeloid leukemia (AML), commonly display constitutive phosphoinositide 3-kinase (PI3K) AKT signaling. However, the exact role of AKT activation in leukemia and its effects on hematopoietic stem cells (HSCs) are poorly understood. Several members of the PI3K pathway, ph...

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Главные авторы: Kharas, Michael G., Okabe, Rachel, Ganis, Jared J., Gozo, Maricel, Khandan, Tulasi, Paktinat, Mahnaz, Gilliland, D. Gary, Gritsman, Kira
Формат: Artigo
Язык:Inglês
Опубликовано: American Society of Hematology 2010
Предметы:
Myeloid Neoplasia
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2826762/
https://ncbi.nlm.nih.gov/pubmed/20008787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-06-229443
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