Constitutively active AKT depletes hematopoietic stem cells and induces leukemia in mice

Human cancers, including acute myeloid leukemia (AML), commonly display constitutive phosphoinositide 3-kinase (PI3K) AKT signaling. However, the exact role of AKT activation in leukemia and its effects on hematopoietic stem cells (HSCs) are poorly understood. Several members of the PI3K pathway, ph...

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Main Authors: Kharas, Michael G., Okabe, Rachel, Ganis, Jared J., Gozo, Maricel, Khandan, Tulasi, Paktinat, Mahnaz, Gilliland, D. Gary, Gritsman, Kira
格式: Artigo
語言:Inglês
出版: American Society of Hematology 2010
主題:
Myeloid Neoplasia
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2826762/
https://ncbi.nlm.nih.gov/pubmed/20008787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-06-229443
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