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Constitutively active AKT depletes hematopoietic stem cells and induces leukemia in mice
Human cancers, including acute myeloid leukemia (AML), commonly display constitutive phosphoinositide 3-kinase (PI3K) AKT signaling. However, the exact role of AKT activation in leukemia and its effects on hematopoietic stem cells (HSCs) are poorly understood. Several members of the PI3K pathway, ph...
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| Hlavní autoři: | , , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Society of Hematology
2010
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2826762/ https://ncbi.nlm.nih.gov/pubmed/20008787 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-06-229443 |
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