A thrombopoietin receptor antagonist is capable of depleting myelofibrosis hematopoietic stem and progenitor cells

Recently, interactions between thrombopoietin (TPO) and its receptor, the myeloproliferative leukemia (MPL) virus oncogene, have been shown to play a role in the development and progression of myeloproliferative neoplasms including myelofibrosis (MF). These observations have led to the development o...

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Veröffentlicht in:Blood
Hauptverfasser: Wang, Xiaoli, Haylock, David, Hu, Cing Siang, Kowalczyk, Wioleta, Jiang, Tianbo, Qiu, Jiajing, Mosoyan, Goar, He, Wu, Marshall, Netonia, Mascarenhas, John, Tarasova, Anna, Brody, Joshua, Winkler, David, Hoffman, Ronald
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2016
Schlagworte:
Myeloid Neoplasia
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4929928/
https://ncbi.nlm.nih.gov/pubmed/27114459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-10-674465
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