Constitutively active AKT depletes hematopoietic stem cells and induces leukemia in mice

Human cancers, including acute myeloid leukemia (AML), commonly display constitutive phosphoinositide 3-kinase (PI3K) AKT signaling. However, the exact role of AKT activation in leukemia and its effects on hematopoietic stem cells (HSCs) are poorly understood. Several members of the PI3K pathway, ph...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Kharas, Michael G., Okabe, Rachel, Ganis, Jared J., Gozo, Maricel, Khandan, Tulasi, Paktinat, Mahnaz, Gilliland, D. Gary, Gritsman, Kira
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2010
Fag:
Myeloid Neoplasia
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2826762/
https://ncbi.nlm.nih.gov/pubmed/20008787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-06-229443
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker