Spatially distinct roles of class Ia PI3K isoforms in the development and maintenance of PTEN hamartoma tumor syndrome

PTEN hamartoma tumor syndrome (PHTS) comprises a collection of genetic disorders associated with germline mutations in the tumor suppressor gene PTEN. Therapeutic options and preventative measures for PHTS are limited. Using both genetically engineered mouse models and pharmacological PI3K isoform-s...

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Detalhes bibliográficos
Main Authors: Wang, Qi, Von, Thanh, Bronson, Roderick, Ruan, Minzi, Mu, Wenxia, Huang, Alan, Maira, Sauveur-Michel, Zhao, Jean J.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2013
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3731546/
https://ncbi.nlm.nih.gov/pubmed/23873941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.216069.113
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