Spatially distinct roles of class Ia PI3K isoforms in the development and maintenance of PTEN hamartoma tumor syndrome

PTEN hamartoma tumor syndrome (PHTS) comprises a collection of genetic disorders associated with germline mutations in the tumor suppressor gene PTEN. Therapeutic options and preventative measures for PHTS are limited. Using both genetically engineered mouse models and pharmacological PI3K isoform-s...

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Autores principales: Wang, Qi, Von, Thanh, Bronson, Roderick, Ruan, Minzi, Mu, Wenxia, Huang, Alan, Maira, Sauveur-Michel, Zhao, Jean J.
Formato: Artigo
Lenguaje:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2013
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Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3731546/
https://ncbi.nlm.nih.gov/pubmed/23873941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.216069.113
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