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Rac1-mediated membrane raft localization of PI3K/p110β is required for its activation by GPCRs or PTEN loss
We aimed to understand how spatial compartmentalization in the plasma membrane might contribute to the functions of the ubiquitous class IA phosphoinositide 3-kinase (PI3K) isoforms, p110α and p110β. We found that p110β localizes to membrane rafts in a Rac1-dependent manner. This localization potent...
Shranjeno v:
| izdano v: | eLife |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
eLife Sciences Publications, Ltd
2016
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5050018/ https://ncbi.nlm.nih.gov/pubmed/27700986 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.17635 |
| Oznake: |
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