Synthesis of Azaphilone-Based Chemical Libraries

Por Achard, Mathieu, Beeler, Aaron B., Porco, John A.
Publicado em 2012

1,2,3,4-Tetrahydro-1,5-naphthyridines and related heterocyclic scaffolds: Exploration of suitable chemistry for library development

Por Woo, Grace H. C., Beeler, Aaron B., Snyder, John K.
Publicado em 2007

Catalytic Enantioselective Alkylative Dearomatization-Annulation: Total Synthesis and Absolute Configuration Assignment of Hyperibone K

Por Qi, Ji, Beeler, Aaron B., Zhang, Qiang, Porco, John A.
Publicado em 2010

Synthesis of a novel chemotype via sequential metal-catalyzed cycloisomerizations

Por Leng, Bo, Chichetti, Stephanie, Su, Shun, Beeler, Aaron B, Porco, John A
Publicado em 2012

Tandem Processes Identified from Reaction Screening: Nucleophilic Addition to Aryl N-Phosphinylimines Employing La(III)-TFAA activation

Por Kinoshita, Hidenori, Ingham, Oscar J., Ong, Winnie W., Beeler, Aaron B., Porco, John A.
Publicado em 2010

Synthesis and Reactivity of Bicyclo[3.2.1]Octanoid- Derived Cyclopropanes

Por Goodell, John R., Poole, Jennifer L., Beeler, Aaron B., Aubé, Jeffrey, Porco, John A.
Publicado em 2011

Multidimensional Screening and Methodology Development for Condensations Involving Complex 1,2-Diketones

Por Goodell, John R., Leng, Bo, Snyder, Tracy K., Beeler, Aaron B., Porco, John A.
Publicado em 2010

Reaction Discovery Employing Macrocycles: Transannular Cyclizations of Macrocyclic Bis-Lactams

Por Han, Chong, Rangarajan, Sathish, Voukides, Alicia C, Beeler, Aaron B., Johnson, Richard, Porco, John A.
Publicado em 2009

Remodeling of the Natural Product Fumagillol Employing a Reaction Discovery Approach

Por Balthaser, Bradley R., Maloney, Meghan C., Beeler, Aaron B., Porco, John A., Snyder, John K.
Publicado em 2011

Multidimensional Reaction Screening for Photochemical Transformations as a Tool for Discovering New Chemotypes

Por Martin, Véronique I., Goodell, John R., Ingham, Oscar J., Porco, John A., Beeler, Aaron B.
Publicado em 2014

Fine-tuning of macrophage activation using synthetic rocaglate derivatives

Por Bhattacharya, Bidisha, Chatterjee, Sujoy, Devine, William G., Kobzik, Lester, Beeler, Aaron B., Porco, John A., Kramnik, Igor
Publicado no Sci Rep (2016)

Identification of Anti-prion Compounds using a Novel Cellular Assay

Por Imberdis, Thibaut, Heeres, James T., Yueh, Han, Fang, Cheng, Zhen, Jessie, Rich, Celeste B., Glicksman, Marcie, Beeler, Aaron B., Harris, David A.
Publicado no J Biol Chem (2016)

A Time-Resolved Fluorescence–Resonance Energy Transfer Assay for Identifying Inhibitors of Hepatitis C Virus Core Dimerization

Por Kota, Smitha, Scampavia, Louis, Spicer, Timothy, Beeler, Aaron B., Takahashi, Virginia, Snyder, John K., Porco, John A., Hodder, Peter, Strosberg, Arthur Donny
Publicado em 2010

Development of an Automated Microfluidic Reaction Platform for Multidimensional Screening: Reaction Discovery Employing Bicyclo[3.2.1]octanoid Scaffolds

Por Goodell, John R., McMullen, Jonathan P., Zaborenko, Nikolay, Maloney, Jason R., Ho, Chuan-Xing, Jensen, Klavs F., Porco, John A., Beeler, Aaron B.
Publicado em 2009

Development of a Potent and Selective HDAC8 Inhibitor

Por Ingham, Oscar J., Paranal, Ronald M., Smith, William B., Escobar, Randolph A., Yueh, Han, Snyder, Tracy, Porco, John A., Bradner, James E., Beeler, Aaron B.
Publicado no ACS Med Chem Lett (2016)

Identification of Novel Epoxide Inhibitors of Hepatitis C Virus Replication Using a High-Throughput Screen

Por Peng , Lee F., Kim, Sun Suk, Matchacheep, Sirinya, Lei, Xiaoguang, Su, Shun, Lin, Wenyu, Runguphan, Weerawat, Choe, Won-Hyeok, Sakamoto, Naoya, Ikeda, Masanori, Kato, Nobuyuki, Beeler, Aaron B., Porco, John A., Schreiber, Stuart L., Chung, Raymond T.
Publicado em 2007

Discovery of new antimalarial chemotypes through chemical methodology and library development

Por Brown, Lauren E., Chih-Chien Cheng, Ken, Wei, Wan-Guo, Yuan, Pingwei, Dai, Peng, Trilles, Richard, Ni, Feng, Yuan, Jing, MacArthur, Ryan, Guha, Rajarshi, Johnson, Ronald L., Su, Xin-zhuan, Dominguez, Melissa M., Snyder, John K., Beeler, Aaron B., Schaus, Scott E., Inglese, James, Porco, John A.
Publicado em 2011