Identification of Novel Epoxide Inhibitors of Hepatitis C Virus Replication Using a High-Throughput Screen

Using our high-throughput hepatitis C replicon assay to screen a library of over 8,000 novel diversity-oriented synthesis (DOS) compounds, we identified several novel compounds that regulate hepatitis C virus (HCV) replication, including two libraries of epoxides that inhibit HCV replication (best 5...

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Detalhes bibliográficos
Main Authors: Peng , Lee F., Kim, Sun Suk, Matchacheep, Sirinya, Lei, Xiaoguang, Su, Shun, Lin, Wenyu, Runguphan, Weerawat, Choe, Won-Hyeok, Sakamoto, Naoya, Ikeda, Masanori, Kato, Nobuyuki, Beeler, Aaron B., Porco, John A., Schreiber, Stuart L., Chung, Raymond T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2007
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2043288/
https://ncbi.nlm.nih.gov/pubmed/17682098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00233-07
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