Reaction Discovery Employing Macrocycles: Transannular Cyclizations of Macrocyclic Bis-Lactams

[Image: see text] Macrocyclic bis-lactams have been synthesized by cyclodimerization of homoallylic amino esters employing a Zr(IV)-catalyzed ester-amide exchange protocol. Base-mediated transannular cyclizations have been identified to access both bicyclic [5-11] and tricyclic [5-8-5] frameworks in...

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Bibliografiske detaljer
Main Authors: Han, Chong, Rangarajan, Sathish, Voukides, Alicia C, Beeler, Aaron B., Johnson, Richard, Porco, John A.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2774802/
https://ncbi.nlm.nih.gov/pubmed/19102683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol802729f
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