A Time-Resolved Fluorescence–Resonance Energy Transfer Assay for Identifying Inhibitors of Hepatitis C Virus Core Dimerization

Binding of hepatitis C virus (HCV) RNA to core, the capsid protein, results in the formation of the nucleocapsid, the first step in the assembly of the viral particle. A novel assay was developed to discover small molecule inhibitors of core dimerization. This assay is based on time-resolved fluores...

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Main Authors: Kota, Smitha, Scampavia, Louis, Spicer, Timothy, Beeler, Aaron B., Takahashi, Virginia, Snyder, John K., Porco, John A., Hodder, Peter, Strosberg, Arthur Donny
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2010
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2971647/
https://ncbi.nlm.nih.gov/pubmed/20035614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/adt.2009.0217
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