Mechanotransduction In Vivo by Repeated Talin Stretch-Relaxation Events Depends upon Vinculin

Por Margadant, Felix, Chew, Li Li, Hu, Xian, Yu, Hanry, Bate, Neil, Zhang, Xian, Sheetz, Michael
Publicado em 2011

Subcellular Localization of Talin Is Regulated by Inter-domain Interactions

Por Banno, Asoka, Goult, Benjamin T., Lee, HoSup, Bate, Neil, Critchley, David R., Ginsberg, Mark H.
Publicado em 2012

The domain structure of talin: Residues 1815–1973 form a five-helix bundle containing a cryptic vinculin-binding site

Por Goult, Benjamin T., Gingras, Alexandre R., Bate, Neil, Barsukov, Igor L., Critchley, David R., Roberts, Gordon C.K.
Publicado em 2010

Talin Contains A C-Terminal Calpain2 Cleavage Site Important In Focal Adhesion Dynamics

Por Bate, Neil, Gingras, Alexandre R., Bachir, Alexia, Horwitz, Rick, Ye, Feng, Patel, Bipin, Goult, Benjamin T., Critchley, David R.
Publicado em 2012

Talin 2 is a large and complex gene encoding multiple transcripts and protein isoforms

Por Debrand, Emmanuel, El Jai, Yasmine, Spence, Lorraine, Bate, Neil, Praekelt, Uta, Pritchard, Catrin A, Monkley, Susan J, Critchley, David R
Publicado em 2009

Mice carrying a complete deletion of the talin2 coding sequence are viable and fertile

Por Debrand, Emmanuel, Conti, Francesco J., Bate, Neil, Spence, Lorraine, Mazzeo, Daniela, Pritchard, Catrin A., Monkley, Susan J., Critchley, David R.
Publicado em 2012

A Conserved Lipid-binding Loop in the Kindlin FERM F1 Domain Is Required for Kindlin-mediated αIIbβ3 Integrin Coactivation

Por Bouaouina, Mohamed, Goult, Benjamin T., Huet-Calderwood, Clotilde, Bate, Neil, Brahme, Nina N., Barsukov, Igor L., Critchley, David R., Calderwood, David A.
Publicado em 2012

The Structure of the Talin Head Reveals a Novel Extended Conformation of the FERM Domain

Por Elliott, Paul R., Goult, Benjamin T., Kopp, Petra M., Bate, Neil, Grossmann, J. Günter, Roberts, Gordon C.K., Critchley, David R., Barsukov, Igor L.
Publicado em 2010

Central Region of Talin Has a Unique Fold That Binds Vinculin and Actin

Por Gingras, Alexandre R., Bate, Neil, Goult, Benjamin T., Patel, Bipin, Kopp, Petra M., Emsley, Jonas, Barsukov, Igor L., Roberts, Gordon C. K., Critchley, David R.
Publicado em 2010

Talin determines the nanoscale architecture of focal adhesions

Por Liu, Jaron, Wang, Yilin, Goh, Wah Ing, Goh, Honzhen, Baird, Michelle A., Ruehland, Svenja, Teo, Shijia, Bate, Neil, Critchley, David R., Davidson, Michael W., Kanchanawong, Pakorn
Publicado no Proc Natl Acad Sci U S A (2015)

Structural studies on full-length talin1 reveal a compact auto-inhibited dimer: Implications for talin activation

Por Goult, Benjamin T., Xu, Xiao-Ping, Gingras, Alexandre R., Swift, Mark, Patel, Bipin, Bate, Neil, Kopp, Petra M., Barsukov, Igor L., Critchley, David R., Volkmann, Niels, Hanein, Dorit
Publicado em 2013

Activation of a vinculin-binding site in the talin rod involves rearrangement of a five-helix bundle

Por Papagrigoriou, Evangelos, Gingras, Alexandre R, Barsukov, Igor L, Bate, Neil, Fillingham, Ian J, Patel, Bipin, Frank, Ronald, Ziegler, Wolfgang H, Roberts, Gordon CK, Critchley, David R, Emsley, Jonas
Publicado em 2004

The Structure of an Interdomain Complex That Regulates Talin Activity

Por Goult, Benjamin T., Bate, Neil, Anthis, Nicholas J., Wegener, Kate L., Gingras, Alexandre R., Patel, Bipin, Barsukov, Igor L., Campbell, Iain D., Roberts, Gordon C. K., Critchley, David R.
Publicado em 2009

The structure of an integrin/talin complex reveals the basis of inside-out signal transduction

Por Anthis, Nicholas J, Wegener, Kate L, Ye, Feng, Kim, Chungho, Goult, Benjamin T, Lowe, Edward D, Vakonakis, Ioannis, Bate, Neil, Critchley, David R, Ginsberg, Mark H, Campbell, Iain D
Publicado em 2009

The Structure of the N-Terminus of Kindlin-1: A Domain Important for αIIbβ3 Integrin Activation

Por Goult, Benjamin T., Bouaouina, Mohamed, Harburger, David S., Bate, Neil, Patel, Bipin, Anthis, Nicholas J., Campbell, Iain D., Calderwood, David A., Barsukov, Igor L., Roberts, Gordon C., Critchley, David R.
Publicado em 2009

RIAM and Vinculin Binding to Talin Are Mutually Exclusive and Regulate Adhesion Assembly and Turnover

Por Goult, Benjamin T., Zacharchenko, Thomas, Bate, Neil, Tsang, Ricky, Hey, Fiona, Gingras, Alexandre R., Elliott, Paul R., Roberts, Gordon C. K., Ballestrem, Christoph, Critchley, David R., Barsukov, Igor L.
Publicado em 2013

Structure of a double ubiquitin-like domain in the talin head: a role in integrin activation

Por Goult, Benjamin T, Bouaouina, Mohamed, Elliott, Paul R, Bate, Neil, Patel, Bipin, Gingras, Alexandre R, Grossmann, J Günter, Roberts, Gordon C K, Calderwood, David A, Critchley, David R, Barsukov, Igor L
Publicado em 2010

Vinculin controls talin engagement with the actomyosin machinery

Por Atherton, Paul, Stutchbury, Ben, Wang, De-Yao, Jethwa, Devina, Tsang, Ricky, Meiler-Rodriguez, Eugenia, Wang, Pengbo, Bate, Neil, Zent, Roy, Barsukov, Igor L., Goult, Benjamin T., Critchley, David R., Ballestrem, Christoph
Publicado no Nat Commun (2015)

The structure of the C-terminal actin-binding domain of talin

Por Gingras, Alexandre R, Bate, Neil, Goult, Benjamin T, Hazelwood, Larnele, Canestrelli, Ilona, Grossmann, J Günter, Liu, HongJun, Putz, Nicholas S M, Roberts, Gordon C K, Volkmann, Niels, Hanein, Dorit, Barsukov, Igor L, Critchley, David R
Publicado em 2008

Studies on the morphology and spreading of human endothelial cells define key inter- and intramolecular interactions for talin1

Por Kopp, Petra M., Bate, Neil, Hansen, Tania M., Brindle, Nicholas P.J., Praekelt, Uta, Debrand, Emmanuel, Coleman, Stacey, Mazzeo, Daniela, Goult, Benjamin T., Gingras, Alexandre R., Pritchard, Catrin A., Critchley, David R., Monkley, Susan J.
Publicado em 2010