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Structural studies on full-length talin1 reveal a compact auto-inhibited dimer: Implications for talin activation
Talin is a large adaptor protein that activates integrins and couples them to cytoskeletal actin. Talin contains an N-terminal FERM (band 4.1, ezrin, radixin, moesin) domain (the head) linked to a flexible rod comprised of 13 amphipathic helical bundles (R1–R13) that terminate in a C-terminal helix...
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| Autori principali: | , , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3799832/ https://ncbi.nlm.nih.gov/pubmed/23726984 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsb.2013.05.014 |
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