Structural studies on full-length talin1 reveal a compact auto-inhibited dimer: Implications for talin activation

Talin is a large adaptor protein that activates integrins and couples them to cytoskeletal actin. Talin contains an N-terminal FERM (band 4.1, ezrin, radixin, moesin) domain (the head) linked to a flexible rod comprised of 13 amphipathic helical bundles (R1–R13) that terminate in a C-terminal helix...

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Hauptverfasser: Goult, Benjamin T., Xu, Xiao-Ping, Gingras, Alexandre R., Swift, Mark, Patel, Bipin, Bate, Neil, Kopp, Petra M., Barsukov, Igor L., Critchley, David R., Volkmann, Niels, Hanein, Dorit
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3799832/
https://ncbi.nlm.nih.gov/pubmed/23726984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsb.2013.05.014
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