Central Region of Talin Has a Unique Fold That Binds Vinculin and Actin

Talin is an adaptor protein that couples integrins to F-actin. Structural studies show that the N-terminal talin head contains an atypical FERM domain, whereas the N- and C-terminal parts of the talin rod include a series of α-helical bundles. However, determining the structure of the central part o...

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Hlavní autoři: Gingras, Alexandre R., Bate, Neil, Goult, Benjamin T., Patel, Bipin, Kopp, Petra M., Emsley, Jonas, Barsukov, Igor L., Roberts, Gordon C. K., Critchley, David R.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2010
Témata:
Protein Structure and Folding
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2937989/
https://ncbi.nlm.nih.gov/pubmed/20610383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.095455
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