Activation of a vinculin-binding site in the talin rod involves rearrangement of a five-helix bundle

The interaction between the cytoskeletal proteins talin and vinculin plays a key role in integrin-mediated cell adhesion and migration. We have determined the crystal structures of two domains from the talin rod spanning residues 482–789. Talin 482–655, which contains a vinculin-binding site (VBS),...

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Detalhes bibliográficos
Main Authors: Papagrigoriou, Evangelos, Gingras, Alexandre R, Barsukov, Igor L, Bate, Neil, Fillingham, Ian J, Patel, Bipin, Frank, Ronald, Ziegler, Wolfgang H, Roberts, Gordon CK, Critchley, David R, Emsley, Jonas
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2004
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC514914/
https://ncbi.nlm.nih.gov/pubmed/15272303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600285
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