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Activation of a vinculin-binding site in the talin rod involves rearrangement of a five-helix bundle
The interaction between the cytoskeletal proteins talin and vinculin plays a key role in integrin-mediated cell adhesion and migration. We have determined the crystal structures of two domains from the talin rod spanning residues 482–789. Talin 482–655, which contains a vinculin-binding site (VBS),...
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| Autors principals: | , , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group
2004
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC514914/ https://ncbi.nlm.nih.gov/pubmed/15272303 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600285 |
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