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Vinculin controls talin engagement with the actomyosin machinery
The link between extracellular-matrix-bound integrins and intracellular F-actin is essential for cell spreading and migration. Here, we demonstrate how the actin-binding proteins talin and vinculin cooperate to provide this link. By expressing structure-based talin mutants in talin null cells, we sh...
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| Publicat a: | Nat Commun |
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| Autors principals: | , , , , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4686655/ https://ncbi.nlm.nih.gov/pubmed/26634421 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10038 |
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