Relief of talin autoinhibition triggers a force-independent association with vinculin

Talin, vinculin, and paxillin are core components of the dynamic link between integrins and actomyosin. Here, we study the mechanisms that mediate their activation and association using a mitochondrial-targeting assay, structure-based mutants, and advanced microscopy. As expected, full-length vincul...

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Foilsithe in:J Cell Biol
Main Authors: Atherton, Paul, Lausecker, Franziska, Carisey, Alexandre, Gilmore, Andrew, Critchley, David, Barsukov, Igor, Ballestrem, Christoph
Formáid: Artigo
Teanga:Inglês
Foilsithe: Rockefeller University Press 2019
Ábhair:
Research Articles
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7039207/
https://ncbi.nlm.nih.gov/pubmed/31816055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201903134
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