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Relief of talin autoinhibition triggers a force-independent association with vinculin

Talin, vinculin, and paxillin are core components of the dynamic link between integrins and actomyosin. Here, we study the mechanisms that mediate their activation and association using a mitochondrial-targeting assay, structure-based mutants, and advanced microscopy. As expected, full-length vincul...

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Detalhes bibliográficos
Publicado no:J Cell Biol
Main Authors: Atherton, Paul, Lausecker, Franziska, Carisey, Alexandre, Gilmore, Andrew, Critchley, David, Barsukov, Igor, Ballestrem, Christoph
Formato: Artigo
Idioma:Inglês
Publicado em: Rockefeller University Press 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7039207/
https://ncbi.nlm.nih.gov/pubmed/31816055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201903134
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