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Relief of talin autoinhibition triggers a force-independent association with vinculin

Talin, vinculin, and paxillin are core components of the dynamic link between integrins and actomyosin. Here, we study the mechanisms that mediate their activation and association using a mitochondrial-targeting assay, structure-based mutants, and advanced microscopy. As expected, full-length vincul...

Täydet tiedot

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Bibliografiset tiedot
Julkaisussa:J Cell Biol
Päätekijät: Atherton, Paul, Lausecker, Franziska, Carisey, Alexandre, Gilmore, Andrew, Critchley, David, Barsukov, Igor, Ballestrem, Christoph
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Rockefeller University Press 2019
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7039207/
https://ncbi.nlm.nih.gov/pubmed/31816055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201903134
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