Relief of talin autoinhibition triggers a force-independent association with vinculin

Talin, vinculin, and paxillin are core components of the dynamic link between integrins and actomyosin. Here, we study the mechanisms that mediate their activation and association using a mitochondrial-targeting assay, structure-based mutants, and advanced microscopy. As expected, full-length vincul...

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Veröffentlicht in:J Cell Biol
Hauptverfasser: Atherton, Paul, Lausecker, Franziska, Carisey, Alexandre, Gilmore, Andrew, Critchley, David, Barsukov, Igor, Ballestrem, Christoph
Format: Artigo
Sprache:Inglês
Veröffentlicht: Rockefeller University Press 2019
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7039207/
https://ncbi.nlm.nih.gov/pubmed/31816055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201903134
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