Human cell-based artificial antigen-presenting cells for cancer immunotherapy

Por Butler, Marcus O., Hirano, Naoto
Publicado em 2014

Pembrolizumab

Por Khoja, Leila, Butler, Marcus O., Kang, S. Peter, Ebbinghaus, Scot, Joshua, Anthony M.
Publicado no J Immunother Cancer (2015)

Induction of HLA-DP4-restricted anti-Survivin Th1 and Th2 responses using an artificial antigen-presenting cell

Por Tanaka, Makito, Butler, Marcus O., Ansén, Sascha, Imataki, Osamu, Berezovskaya, Alla, Nadler, Lee M., Hirano, Naoto
Publicado em 2011

Dissociation of its opposing immunologic effects is critical for the optimization of anti-tumor CD8(+) T cell responses induced by IL-21

Por Ansén, Sascha, Butler, Marcus O., Berezovskaya, Alla, Murray, Andrew P., Stevenson, Kristen, Nadler, Lee M., Hirano, Naoto
Publicado em 2008

Specific roles of each TCR hemichain in generating functional chain-centric TCR

Por Nakatsugawa, Munehide, Yamashita, Yuki, Ochi, Toshiki, Tanaka, Shinya, Chamoto, Kenji, Guo, Tingxi, Butler, Marcus O., Hirano, Naoto
Publicado no J Immunol (2015)

Mouse and Human CD1d-Self-Lipid Complexes Are Recognized Differently by Murine Invariant Natural Killer T Cell Receptors

Por Guo, Tingxi, Chamoto, Kenji, Nakatsugawa, Munehide, Ochi, Toshiki, Yamashita, Yuki, Anczurowski, Mark, Butler, Marcus O., Hirano, Naoto
Publicado no PLoS One (2016)

Identification of an immunogenic CD8(+) T-cell epitope derived from γ-globin, a putative tumor-associated antigen for juvenile myelomonocytic leukemia

Por Hirano, Naoto, Butler, Marcus O., Xia, Zhinan, Berezovskaya, Alla, Murray, Andrew P., Ansén, Sascha, Kojima, Seiji, Nadler, Lee M.
Publicado em 2006

Real-world efficacy, toxicity and clinical management of ipilimumab treatment in metastatic melanoma

Por KHOJA, LEILA, ATENAFU, ESHETU G., YE, QIAN, GEDYE, CRAIG, CHAPPELL, MARYANNE, HOGG, DAVID, BUTLER, MARCUS O., JOSHUA, ANTHONY M.
Publicado no Oncol Lett (2016)

Patterns of response to anti-PD-1 treatment: an exploratory comparison of four radiological response criteria and associations with overall survival in metastatic melanoma patients

Por Khoja, Leila, Kibiro, Minnie, Metser, Ur, Gedye, Craig, Hogg, David, Butler, Marcus O, Atenafu, Eshetu G, Joshua, Anthony M
Publicado no Br J Cancer (2016)

Transient stimulation expands superior antitumor T cells for adoptive therapy

Por Kagoya, Yuki, Nakatsugawa, Munehide, Ochi, Toshiki, Cen, Yuchen, Guo, Tingxi, Anczurowski, Mark, Saso, Kayoko, Butler, Marcus O., Hirano, Naoto
Publicado no JCI Insight (2017)

Engagement of CD83 ligand induces prolonged expansion of CD8(+) T cells and preferential enrichment for antigen specificity

Por Hirano, Naoto, Butler, Marcus O., Xia, Zhinan, Ansén, Sascha, von Bergwelt-Baildon, Michael S., Neuberg, Donna, Freeman, Gordon J., Nadler, Lee M.
Publicado em 2006

IL-21 can supplement suboptimal Lck-independent MAPK activation in a STAT-3-dependent manner in human CD8(+) T cells

Por Imataki, Osamu, Ansén, Sascha, Tanaka, Makito, Butler, Marcus O., Berezovskaya, Alla, Milstein, Matthew I., Kuzushima, Kiyotaka, Nadler, Lee M., Hirano, Naoto
Publicado em 2012

Optimization of T-cell reactivity by exploiting TCR chain centricity for the purpose of safe and effective antitumor TCR gene therapy

Por Ochi, Toshiki, Nakatsugawa, Munehide, Chamoto, Kenji, Tanaka, Shinya, Yamashita, Yuki, Guo, Tingxi, Fujiwara, Hiroshi, Yasukawa, Masaki, Butler, Marcus O., Hirano, Naoto
Publicado no Cancer Immunol Res (2015)

BET bromodomain inhibition enhances T cell persistence and function in adoptive immunotherapy models

Por Kagoya, Yuki, Nakatsugawa, Munehide, Yamashita, Yuki, Ochi, Toshiki, Guo, Tingxi, Anczurowski, Mark, Saso, Kayoko, Butler, Marcus O., Arrowsmith, Cheryl H., Hirano, Naoto
Publicado no J Clin Invest (2016)

The full blood count as a biomarker of outcome and toxicity in ipilimumab‐treated cutaneous metastatic melanoma

Por Khoja, Leila, Atenafu, Eshetu G., Templeton, Arnoud, Qye, Ye, Chappell, Mary Anne, Saibil, Sam, Hogg, David, Butler, Marcus O., Joshua, Anthony M.
Publicado no Cancer Med (2016)

A panel of human cell-based artificial APC enables the expansion of long-lived antigen-specific CD4(+) T cells restricted by prevalent HLA-DR alleles

Por Butler, Marcus O., Ansén, Sascha, Tanaka, Makito, Imataki, Osamu, Berezovskaya, Alla, Mooney, Mary M., Metzler, Genita, Milstein, Matthew I., Nadler, Lee M., Hirano, Naoto
Publicado em 2010

CDR3β sequence motifs regulate autoreactivity of human invariant NKT cell receptors

Por Chamoto, Kenji, Guo, Tingxi, Imataki, Osamu, Tanaka, Makito, Nakatsugawa, Munehide, Ochi, Toshiki, Yamashita, Yuki, Saito, Akiko M., Saito, Toshiki I., Butler, Marcus O., Hirano, Naoto
Publicado no J Autoimmun (2015)

CD4(+) and CD8(+) TCRβ repertoires possess different potentials to generate extraordinarily high-avidity T cells

Por Nakatsugawa, Munehide, Rahman, Muhammed A., Yamashita, Yuki, Ochi, Toshiki, Wnuk, Piotr, Tanaka, Shinya, Chamoto, Kenji, Kagoya, Yuki, Saso, Kayoko, Guo, Tingxi, Anczurowski, Mark, Butler, Marcus O., Hirano, Naoto
Publicado no Sci Rep (2016)

Ex Vivo Expansion of Human CD8(+) T Cells Using Autologous CD4(+) T Cell Help

Por Butler, Marcus O., Imataki, Osamu, Yamashita, Yoshihiro, Tanaka, Makito, Ansén, Sascha, Berezovskaya, Alla, Metzler, Genita, Milstein, Matthew I., Mooney, Mary M., Murray, Andrew P., Mano, Hiroyuki, Nadler, Lee M., Hirano, Naoto
Publicado em 2012

Key residues at third CDR3β position impact structure and antigen recognition of human invariant natural killer T cell receptors

Por Chamoto, Kenji, Guo, Tingxi, Scally, Stephen W., Kagoya, Yuki, Ancruzowski, Mark, Wang, Chung-Hsi, Rahman, Muhammed A., Saso, Kayoko, Butler, Marcus O., Chiu, Priscilla P. L., Julien, Jean-Philippe, Hirano, Naoto
Publicado no J Immunol (2016)