CD4(+) and CD8(+) TCRβ repertoires possess different potentials to generate extraordinarily high-avidity T cells

Recent high throughput sequencing analysis has revealed that the TCRβ repertoire is largely different between CD8(+) and CD4(+) T cells. Here, we show that the transduction of SIG35α, the public chain-centric HLA-A*02:01(A2)/MART1(27–35) TCRα hemichain, conferred A2/MART1(27–35) reactivity to a subs...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Nakatsugawa, Munehide, Rahman, Muhammed A., Yamashita, Yuki, Ochi, Toshiki, Wnuk, Piotr, Tanaka, Shinya, Chamoto, Kenji, Kagoya, Yuki, Saso, Kayoko, Guo, Tingxi, Anczurowski, Mark, Butler, Marcus O., Hirano, Naoto
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4814874/
https://ncbi.nlm.nih.gov/pubmed/27030642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep23821
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