BET bromodomain inhibition enhances T cell persistence and function in adoptive immunotherapy models

Adoptive immunotherapy is a potentially curative therapeutic approach for patients with advanced cancer. However, the in vitro expansion of antitumor T cells prior to infusion inevitably incurs differentiation towards effector T cells and impairs persistence following adoptive transfer. Epigenetic p...

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Detalles Bibliográficos
Publicado en:J Clin Invest
Main Authors: Kagoya, Yuki, Nakatsugawa, Munehide, Yamashita, Yuki, Ochi, Toshiki, Guo, Tingxi, Anczurowski, Mark, Saso, Kayoko, Butler, Marcus O., Arrowsmith, Cheryl H., Hirano, Naoto
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2016
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5004946/
https://ncbi.nlm.nih.gov/pubmed/27548527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI86437
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