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Dissociation of its opposing immunologic effects is critical for the optimization of anti-tumor CD8(+) T cell responses induced by IL-21

PURPOSE: IL-21 is a promising new cytokine, which is undergoing clinical testing as an anti-cancer agent. Although IL-21 provides potent stimulation of CD8(+) T cells, it has also been suggested that IL-21 is immunosuppressive by counteracting the maturation of dendritic cells (DC). Dissociation of...

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Main Authors: Ansén, Sascha, Butler, Marcus O., Berezovskaya, Alla, Murray, Andrew P., Stevenson, Kristen, Nadler, Lee M., Hirano, Naoto
Formato: Artigo
Idioma:Inglês
Publicado: 2008
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2570356/
https://ncbi.nlm.nih.gov/pubmed/18829491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-08-1146
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