A panel of human cell-based artificial APC enables the expansion of long-lived antigen-specific CD4(+) T cells restricted by prevalent HLA-DR alleles

Many preclinical experiments have attested to the critical role of CD4(+) T cell help in CD8(+) cytotoxic T lymphocyte (CTL)-mediated immunity. Recent clinical trials have demonstrated that reinfusion of CD4(+) T cells can induce responses in infectious diseases and cancer. However, few standardized...

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Bibliographic Details
Main Authors: Butler, Marcus O., Ansén, Sascha, Tanaka, Makito, Imataki, Osamu, Berezovskaya, Alla, Mooney, Mary M., Metzler, Genita, Milstein, Matthew I., Nadler, Lee M., Hirano, Naoto
Format: Artigo
Language:Inglês
Published: Oxford University Press 2010
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Original Research Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2994545/
https://ncbi.nlm.nih.gov/pubmed/21059769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/intimm/dxq440
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