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IL-21 can supplement suboptimal Lck-independent MAPK activation in a STAT-3-dependent manner in human CD8(+) T cells
Although both MHC class II/CD8α double knock out and CD8β null mice show a defect in the development of MHC class I-restricted CD8(+) T cells in the thymus, they possess low numbers of high avidity peripheral CTL with limited clonality and are able to contain acute and chronic infections. This in vi...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3273545/ https://ncbi.nlm.nih.gov/pubmed/22238455 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1003446 |
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