IL-21 can supplement suboptimal Lck-independent MAPK activation in a STAT-3-dependent manner in human CD8(+) T cells

Although both MHC class II/CD8α double knock out and CD8β null mice show a defect in the development of MHC class I-restricted CD8(+) T cells in the thymus, they possess low numbers of high avidity peripheral CTL with limited clonality and are able to contain acute and chronic infections. This in vi...

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Bibliografiske detaljer
Main Authors: Imataki, Osamu, Ansén, Sascha, Tanaka, Makito, Butler, Marcus O., Berezovskaya, Alla, Milstein, Matthew I., Kuzushima, Kiyotaka, Nadler, Lee M., Hirano, Naoto
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3273545/
https://ncbi.nlm.nih.gov/pubmed/22238455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1003446
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