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Dissociation of its opposing immunologic effects is critical for the optimization of anti-tumor CD8(+) T cell responses induced by IL-21
PURPOSE: IL-21 is a promising new cytokine, which is undergoing clinical testing as an anti-cancer agent. Although IL-21 provides potent stimulation of CD8(+) T cells, it has also been suggested that IL-21 is immunosuppressive by counteracting the maturation of dendritic cells (DC). Dissociation of...
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| Auteurs principaux: | , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2008
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2570356/ https://ncbi.nlm.nih.gov/pubmed/18829491 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-08-1146 |
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