Optimization of T-cell reactivity by exploiting TCR chain centricity for the purpose of safe and effective antitumor TCR gene therapy

Adoptive transfer of T cells redirected by a high affinity antitumor T-cell receptor (TCR) is a promising treatment modality for cancer patients. Safety and efficacy depend on the selection of a TCR that induces minimal toxicity and elicits sufficient antitumor reactivity. Many, if not all, TCRs pos...

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Detalhes bibliográficos
Publicado no:Cancer Immunol Res
Main Authors: Ochi, Toshiki, Nakatsugawa, Munehide, Chamoto, Kenji, Tanaka, Shinya, Yamashita, Yuki, Guo, Tingxi, Fujiwara, Hiroshi, Yasukawa, Masaki, Butler, Marcus O., Hirano, Naoto
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4561213/
https://ncbi.nlm.nih.gov/pubmed/25943533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-14-0222
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